Journal of the European Academy of Dermatology & Venerology 1996;7:294-95. The laxative in aloe Vera can lead to an abortion or speed up the process of labour which is not good for the health of the mother or the baby. Aloe might decrease clotting of the blood. Cochrane.Database.Syst.Rev. Treatment of experimental frostbite with pentoxifylline and aloe vera cream. A double-blind trial of a celandin, aloevera and psyllium laxative preparation in adult patients with constipation. Contact Dermatitis 2007;57(4):278-279. View abstract. J Altern.Complement Med. Hunter, D. and Frumkin, A. View abstract. Arch Dermatol. But it doesn't seem to reduce the number of stretch marks. View abstract. Yagi, A., Kabash, A., Mizuno, K., Moustafa, S. M., Khalifa, T. I., and Tsuji, H. Radical Scavenging Glycoprotein Inhibiting Cyclooxygenase-2 and Thromboxane A2 Synthase from Aloe vera Gel. View abstract. Kumari, S., Harjai, K., and Chhibber, S. Topical treatment of Klebsiella pneumoniae B5055 induced burn wound infection in mice using natural products. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, What Psoriatic Arthritis Really Feels Like, Video: Get Makeup Tips for Concealing Psoriasis. Schmidt JM and Greenspoon JS. View abstract. 2013;(577):1-266. Aloe vera extract 0.5% in a hydrophilic cream versus Aloe vera gel for the management of genital herpes in males. Interventions for preventing oral mucositis for patients with cancer receiving treatment. View abstract. Side Effects of Cape Aloe. 2012;31:95-103. View abstract. Sores in the mouth from injury or rubbing (traumatic oral ulcers). Successful treatment of acute radiation proctitis with aloe vera: a preliminary randomized controlled clinical trial. Rev.Bras.Enferm. J Am Acad Dermatol 1988;18:714-20. 2003;31:40-2. López-Jornet P, Camacho-Alonso F, Molino-Pagan D. Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. Fogleman, R. W., Shellenberger, T. E., Balmer, M. F., Carpenter, R. H., and McAnalley, B. H. Subchronic oral administration of acemannan in the rat and dog. View abstract. But other research suggests that using a salt water spray containing aloe and other ingredients does reduce the severity of sores compared to a control salt water spray. 1998;86:550-6. Radiat Oncol 2013;8:57. J Ethnopharmacol. View abstract. Efficacy of aloe vera gel in the treatment of vulval lichen planus. Compr Child Adolesc Nurs. Interventions for preventing oral mucositis for patients with cancer receiving treatment. J Clin Epidemiol 1997;50(suppl 1):3S. IV. View abstract. View abstract. View abstract. Heck E and Head M. Aloe vera gel cream as a topical treatment for outpatient burns. Aloe vera side effects include hepatitis and thyroid dysfunction along with the abnormal lowering of the blood glucose levels. this site complies with the HONcode standard for trustworthy health information: Coopoosamy RM, Naidoo KK. Stimulant laxatives can decrease potassium levels in the body. When taken in large doses for an extended time, aloe juice may cause other serious problems, including heart disorders, muscle weakness, diarrhea, and weight loss. Savchak VI. Radiology 1939;32:598-599. Olatunya OS, Olatunya AM, Anyabolu HC, et al. Langmead L, Makins RJ, Rampton DS. There has been one report that using the gel as standard wound therapy delayed healing. 2020;32(8):e13860. View abstract. Khorasani G, Hosseinimehr SJ, Azadbakht M, et al. J Altern Complement Med. View abstract. Worthington HV, Clarkson JE, Bryan G, et al. One of the best benefits associated with Aloe ferox is that it can be used on all types of skin. Clinical trial of Aloe vera linn. 1986;24(4):288-294. View abstract. Final rule. Natl Toxicol Program Tech Rep Ser. J Altern Complement Med. Ai.Zheng. When taken by mouth aloe latex is a type of laxative called a stimulant laxative. Williams MS, Burk M, Loprinzi CL, et al. Eur Rev Med Pharmacol Sci 2014;18(7):1078-84. Early research suggests that applying an aloe cream three times daily for at least 3 weeks can improve pain and wound healing in people with this condition. Aloe vera leaf gel: a review update. Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. Ghannam, N., Kingston, M., Al Meshaal, I. Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. 2013;131(1):26-39. Plast Reconstr Surg. Najafian Y, Mazloum Z, Najaf Najafi M, Hamedi S, Mahjour M, Feyzabadi Z. Efficacy of Aloe vera/ Plantago major gel in diabetic foot ulcer: a randomized double-blind clinical trial. The bio-active compounds in aloe vera might interfere with liver's detoxification process, further causing health complications. View abstract. Burns 1981;7(4):291-294. 2011;10(12):1455-1461. Health News 2004;10(6):2. It can also trigger … Stimulant laxatives speed up the bowels. View abstract. 2018 Jul;31(13):1703-1708. doi: 10.1080/14767058.2017.1325865. View abstract. View abstract. Puentes Sanchez J., Pardo Gonzalez, C. M., Pardo Gonzalez, M. B., Navarro Casado, F. J., Puentes, Sanchez R., Mendez Gonzalez, J. M., Gonzalez, Rojo J., Juarez, Morales A., and Lopez, Fernandez, I. Information from this source is evidence-based and objective, and without commercial influence. Bruce, S. and Watson, J. Wounds 1994;6:4. African Cape Aloe … Phillips T, Ongenae K Kanj L Slater-Freedberg J. Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Clin Oncol.(R.Coll.Radiol.) Fulton, J. E., Jr. Also, it aggravates health conditions such as Crohns disease, ulcerative colitis, hemorrhoids, etc. 1973;12(1):68-73. 2006;12:241-6. Collins EE and Collins C. Roentgen dermatitis treated with fresh whole leaf of aloe vera. But it does not seem to improve the ability to open the mouth or improve cheek and. 2013 May;19(5):425-8. Effects of low-dose Aloe sterol supplementation on skin moisture, collagen score and objective or subjective symptoms: 12-week, double-blind, randomized controlled trial. List of various diseases cured by Aloe Ferox. Syed TA, Ahmad SA, Holt AH, et al. 2006;29(10):25-30. 2007;2:45. A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Kaufman T, Kalderon N, Ullmann Y, Berger J. Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study. Oyelami OA, Onayemi A, Oyedeji OA, et al. Puvabanditsin P, Vongtongsri R. Efficacy of aloe vera cream in prevention and treatment of sunburn and suntan. Rev Enferm. Worthington, H. V., Clarkson, J. E., Bryan, G., Furness, S., Glenny, A. M., Littlewood, A., McCabe, M. G., Meyer, S., and Khalid, T. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Some aloe products are made from the whole crushed leaf, so they contain both gel and latex. View abstract. 1998;11:273-6. Cutan Ocul Toxicol. Schorkhuber M, Richter M, Dutter A, et al. Zhong.Yao Cai. A., Tariq, M., Parman, N. S., and Woodhouse, N. The antidiabetic activity of aloes: preliminary clinical and experimental observations. View abstract. There were several isolated cases that cape aloe may have caused acute kidney failure and liver dysfunction. View abstract. J Altern Complement Med. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96. Thongprasom K, Carrozzo M, Furness S, et al. Rajar UD, Majeed R, Parveen N, et al. Nelemans FA. Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Aloe gel applied to the skin may cause burning and itching. Plemons J, Rees TD Binnie WH Wright JM. 2008;18:612-4. Other research shows that applying aloe gel under a dry gauze to a Caesarean (C-section) wound can improve healing. Because cape aloe latex is so potent, the University of Maryland Medical Center cautions against using it as a single-ingredient medication for constipation. Phytomedicine 1996;3:241-3. View abstract. Choi HC, Kim SJ, Son KY, Oh BJ, Cho BL. Wright CS. Skin Pharmacol Physiol. WebMD does not provide medical advice, diagnosis or treatment. What is bitter aloe? Puataweepong P, Dhanachai M, Dangprasert S, et al. 1991;49:65-71. 2009;23:171-5. Taking aloe gel along with diabetes medications might cause your blood sugar to go too low. Surakunprapha P, Winaikosol K, Chowchuen B, Punyavong P, Jenwitheesuk K, Jenwitheesuk K. A prospective randomized double-blind study of silicone gel plus herbal extracts versus placebo in pre-sternal hypertrophic scar prevention and amelioration. Skin Res Technol. II. J Infect.Dev Ctries. Worthington, H. V., Clarkson, J. E., and Eden, O. Photodermatol. Planta Med 2002;68(11):957-960. Phytomedicine 1996;3(3):241-243. 2010 Nov 9;4:e879. Aloe vera in the treatment of roentgen ulcers and telangiectasis. Olsen DL, Raub W, Bradley C, et al. Inhibition of Cl- channels as a possible base of laxative action of certain anthraquinones and anthrones. View abstract. The effect of aloe gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. A randomised study of an Aloe vera derivative gel dressing versus conventional treatment after shave biopsy excisions. 1996;55(1):69-75. View abstract. Preliminary trial of aloe vera gruel on HIV infection. View abstract. Int J Radiat Oncol Biol Phys 1996;36:345-9. View abstract. Stimulant laxatives speed up the bowels and can cause diarrhea in some people. Bunyapraphatsara, N., Yongchaiyudha, S., Rungpitarangsi, V., and Chokechaijaroenporn, O. Antidiabetic activity of Aloe vera L. juice II. Small tears in the lining of the anus (anal fissures). Cancer. A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. View abstract. (3). Eur Arch Paediatr Dent. Esua, M. F. and Rauwald, J. W. Novel bioactive maloyl glucans from aloe vera gel: isolation, structure elucidation and in vitro bioassays. View abstract. Fogleman, R. W., Chapdelaine, J. M., Carpenter, R. H., and McAnalley, B. H. Toxicologic evaluation of injectable acemannan in the mouse, rat and dog. Sudarshan R, Annigeri RG, Sree Vijayabala G. Aloe vera in the treatment for oral submucous fibrosis - a preliminary study. Quintessence Int 2012;43(9):793-800. View abstract. Contact dermatitis to Aloe arborescens. J Derm Treatment 1999;10(1):7-11. View abstract. When taken orally aloe latex is a type of laxative called a stimulant laxative. Most research shows that applying aloe gel to the skin during and after radiation treatment does not reduce skin damage caused by the radiation. Br J Dermatol. [The modulating of aloe polysaccharides on the cell cycle and cycle regulating protein expression in X-ray irradiated non-malignant cells]. Hutter JA, Salman M, Stavinoha WB, et al. BMJ Case Rep 2012;2012. A randomised study of an Aloe vera derivative gel dressing versus conventional treatment after shave biopsy excisions. Phytomedicine 2000;7(3):209-219. Curr Drug Discov Technol. But not all research agrees. Some research shows that using an aloe solution 2-3 times daily during radiation therapy or chemotherapy can make this condition less severe. View abstract. Some research even suggests that aloe might slow down wound healing. Journal of the European Academy of Dermatology & Venerology 1996;7(3):294-295. Contact Dermatitis 1984;11(1):51. Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers. J Oral Pathol Med 2012;41(10):755-61. Richardson, J., Smith, J. E., McIntyre, M., Thomas, R., and Pilkington, K. Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. A case of acute liver damage after aloe vera ingestion has been reported. Dick WR, Fletcher EA, Shah SA. J Pharm Pharmacol 2000;52(5):593-598. 2010;39(10):735-740. The aloe cream was used along with a sitz bath three times daily, laxatives, and eating a full fiber diet. Rieger, L. and Carson, R. E. The clinical effects of saline and aloe vera rinses on periodontal surgical sites. … Possible interaction between sevoflurane and Aloe vera. 2010;105(5):404-405. Other symptoms of IBS include cramping, abdominal pain, flatulence, and bloating. Common side effects of aloe include: blood sugar (hypoglycemia) Burning and itching of the skin (infrequent) Stomach pain and cramps (high doses) Asian Biomedicine 2009;3(4):375-382. Chalaprawat M. The hypoglycemic effects of aloe vera in Thai diabetic patients. The efficacy of oral Aloe vera for radiation induced mucositis in head and neck cancer patients: a double-blind placebo controlled study. Cochrane Database Syst Rev. Neurogastroenterol Motil. Investigations of the laxative action of aloin in the human colon. Korean J Gastroenterol 2014;64(1):54-8. It is generally recognized as safe (GRAS), has no known negative side effects, and is rich in plant … Rabe C, Musch A, Schirmacher P, et al. 2009;39:587-91. Melanoma Res 2005;15(6):489-494. However, the FDA has approved its use as a food additive. Surg Today. Di Franco R, Sammarco E, Calvanese MG, De Natale F, Falivene S, Di Lecce A, Giugliano FM, Murino P, Manzo R, Cappabianca S, Muto P, Ravo V. Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams. Obstetrics & Gynecology 1991;78(1):115-117. Fitoterapia 2007;78(3):219-222. View abstract. View abstract. Lasers Surg Med. View abstract. What factors influenced or will influence your purchase? ENCOURAGE A HEALTHY DIGESTIVE SYSTEM: Within the “sap” of the Cape Aloe … Koch A. But more research is needed to confirm. Use caution with cosmetic products containing A. vera gel. View abstract. Bitter aloe is among the tallest of the more than 400 aloe species and can be found in the Cape Region of South Africa. J Altern Complement Med 2010;16:647-50. Some research shows that applying an aloe cream to hemorrhoid-related wounds can help the wounds heal and provide some pain relief. Acute bullous allergic dermatitis due to local application of aloe leaves. Reddy RL, Reddy RS, Ramesh T, Singh TR, Swapna LA, Laxmi NV. Biochim Biophys Acta 1999;1428:406-14. Quiz: What Do You Know About Vitamin B12 Deficiency? The effects of aloe vera on wound healing in cell proliferation, migration, and viability. Angiology 1985;36(8):485-492. chinensis. Most research shows that applying aloe gel or cream to the skin can reduce healing time in people with first- or second-degree burns. Other research suggests that wearing gloves coated in aloe improves symptoms of dry skin in women. View abstract. Monitor your blood sugar closely. It may cause gastrointestinal problems, stomach … View abstract. 1996;12:153-7. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Horm.Res. Sakai R. Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet. Avoid aloe juice during pregnancy or breast-feeding. Am J Med Sci. Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others. 2020. J Matern Fetal Neonatal Med. In Vivo. Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Merchant TE, Bosley C, Smith J, et al. View abstract. Clinical trial in new cases of diabetes mellitus. No doi. Herbal remedy-associated acute renal failure secondary to Cape aloes. Burns 2003;28:834-6.. View abstract. Ann Pharmacother 2007;41:1740-3. Names of Aloe … Arch Otolaryngol Head Neck Surg 1995;121:678-80. Thamlikitkul V, Bunyapraphatsara N Riewpaiboon W Theerapong S Chantrakul C et al. These effects combined suggest that Cape Aloe gel can speed up the process of wound healing. Evaluation of the anti-angiogenic effect of aloe-emodin. Some drugs and herbal products: IARC monographs on the evaluation of carcinogenic risks to humans, Volume 108. Aloe latex can cause stomach pain … Clinical and toxicological aspects of anthraquinone laxatives. 2020;20(1):146. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children. Cutis 1991;47(3):193-196. 2012;65(2):374-378. When taken orally, aloe latex is a type of laxative called a stimulant laxative. Skin Pharmacol Physiol. View abstract. Klein AD, Penneys NS. Do not take aloe by mouth if you are having surgery within 2 weeks. Morales-Bozo, I., Rojas, G., Ortega-Pinto, A., Espinoza, I., Soto, L., Plaza, A., Lozano, C., and Urzua, B. View abstract. 2012;18:2026-34. Wang, Z., Huang, Z., Wu, Q., Zhou, J., Zhu, X., Li, Q., and Liu, Z. Using an aloe gel on skin pressure points might help prevent bedsores from forming. 37-71. Ann.Oncol. Hajhashemi M, Rafieian M, Rouhi Boroujeni HA, Miraj S, Memarian S, et al. Puataweepong P, Dhanachai M Dangprasert S Sithatani C Sawangsilp T Narkwong L et al. Medications taken by mouth (Oral drugs) interacts with ALOE. Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Altern Complement Med. Research suggests that applying an aloe gel in the morning and evening, in addition to a prescription anti-acne medicine, improves acne by about 35% in both children and adults. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, and et al. Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. 2012;18:850-3. View abstract. Mol Med Rep 2018;18(3):3537-43. doi: 10.3892/mmr.2018.9319. How Aloe Ferox is effective for various diseases is listed in repertory format. Cancer Nurs 2002;25:442-51.. View abstract. Antidiabetic activity of aloe vera L. juice. Endocr.Metab Immune.Disord Drug Targets. Plemons J, Rees TD Binnie WH, et al. View abstract. View abstract. Non-randomized open clinical evaluation on the effectiveness of "Mepentol Leche"]. Int J Dermatol. Status of certain additional over-the counter drug category II and III active ingredients. A double-blind clinical study in humans. Mandeville FB. Wounds. A placebo-controlled, double-blind, comparative study.

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