Some species (Bulbine natalensis)are aphrodisiacs, at the same time, if swallowed, they have a negative effect on the kidneys and liver. Biochem Pharmacol. PubChem integrated platform of small molecules and biological activities. Nucleic Acids Res. Anticancer and mode of action of various phytochemicals present in the plant not yet has been studied. 2009;1:4–18. Matsui WH. Bolton EE, Wang Y, Thiessen PA, Bryant SH. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. Bulbine was named a 2006 Plant of the Year by the Florida Nursery Growers and Landscape Association. Neoplasia. Adaptation to this condition often resulted in chemotherapeutic resistance in cancer cells. It might be toxic to the embryo or fetus. 2011;8:150–08. Growing Bulbine flowers is a good choice for gardens in arid areas, as Bulbine plants are drought tolerant. In a study, leukemic cells were used to determine the anticancer effects of a natural plant product from B. frutescens. 2003. p. 418–20. Lee SK, Lee IH, Kim HJ, Chang GS, Chung JE, No KT. Bulbine frutescens works great as a low border plant in succulent gardens and could be used among rocks in xeriscape plantings. Although normal cells also express caspase-3 genes during apoptosis, this study focused exclusively on the effect of Bulbine natalensis and B. frutescens fractions (selected relative to the cytotoxicity results of B. natalensis) on the HEp-2 cell line (read cell culture and … Bulbine natalensis is a succulent plant that grows in parts of South Africa. The Bulbine frutescens extract is used in the therapeutic or cosmetic fields and has an especially good effect on diseases of the skin and mucous membranes, in particular infections or inflammations such as fungal diseases, in prevention and/or curing injuries to the skin and mucous membranes, in particular burn wounds, as a disinfectant, as an agent to improve the immune defense, for body care, oral care, … Importance of Bulbine. This is a very small plant. J Cheminform. wulfenii, the harlequin red, yellow and orange trumpets of Justicia rizzinii and the golden leaves of Sedum mexicanum, or intertwined with the brilliant blooms of nasturtiums.The genus Bulbine belongs to the family Xanthorrhoeaceae, which includes genera such as Asphodelus, Dianella, Hemerocallis, Kniphofia and Phormium. Cite as. It gets about a 1′ tall and spreads to about 2 feet. Anticancer and mode of action of various phytochemicals present in the plant not yet has been studied. Part of Springer Nature. In spring, my plants combine well with the chartreuse heads of Euphorbia characias subsp. ... (Bulbine bulbosa) is regarded as a toxic plant, as it can poison cattle. Tambama P, Abegaz B, Mukanganyama S. Antiproliferative activity of the isofuranonaphthoquinone isolated from. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. ... Fenugreek seeds protect the liver from alcohol toxicity. Lead phytochemicals showed better ADME/T, drug-likeness, xenobiotic enzymes interactions and biological activities. Dallakyan S. PyRx-python prescription v. 0.8. This service is more advanced with JavaScript available, Phytochemistry: An in-silico and in-vitro Update 2010;31:455–61. Bulbine frutescens is a traditional medicinal plant of South Africa, has been preliminarily reported for anti-proliferative and anti-drug resistance property in cancer cells. Chen X, Du Y, Nan J, Zhang X, Qin X, Wang Y, Hou J, Wang Q, Yang J. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. The correction to this chapter is available at  https://doi.org/10.1007/978-981-13-6920-9_32. Bulbine frutescens is often used in landscaping where a drought-resistant, tough groundcover is required.. Growing Bulbine Bulbine is very easy to grow, requiring little water and minimum care. Bulbine frutescens Wu T, Chen C, Li F, Chen Z, Xu Y, Xiao B, Tao Z. Bulbine natalensis and Bulbine frutescens promote cutaneous wound healing. 2005;7:509–21. pp 491-510 | UCSF Chimera- a visualization system for exploratory research and analysis. The contact medium comprises an expressed gel from the plant Bulbine frutescens and may contain asiaticoside and panthenol. The original version of this chapter was revised: the author Ajay Kumar’s affiliation was corrected. 2013;8:e63697. It makes a nice succulent ground cover and blooms throughout the year. This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. Due to its influences on cognition and sexuality, it is currently being investigated for its effects on testosterone. Widgerow AD, Chait LA, Stals R, Stals PJ. PPK and SK acknowledges financial support from UGC, India and Central University of Punjab Bathinda, Punjab, India for providing financial assistance in the form of UGC-CSIR Senior Research Fellowship and UGC-BSR Research Start-Up-Grant, [No.F.30-372/2017(BSR)] respectively. Induction of phase I, II and III drug metabolism/transport by xenobiotics. It hails from Africa and is a good groundcover plant for dry parts of the garden. Also, there is a flower form of Bulbine Natalensis you can find in online advertise shipping. The authors declare that they have no conflict of interest. Bulbine. Then, you can buy other forms of Bulbine Natalensis such as capsuled extract that sold by online markets. Annu Rep Comput Chem. Adv Cancer Res. Another type of contrast, much used in the Pretoria NBG, is the inclusion of grey or whitish-leaved plants among the green ones. The present in silico study was designed to assess the potential B. frutescens phytochemicals as novel natural inhibitors of signaling proteins involved in cancer. It is generally sold under the scientific name Bulbine frutescens, though some nurseries use the synonyms B. fruticosum or B. caulescens. Cancer Agenda. For the first time Palmidin C, AC1NSTKE, Bulbine-knipholone and 4′-Demethylknipholone 2′-β-D-glucopyranoside compounds have been reported for their anticancer potential. In fact, there will be 30 mg per 1 g of serving size is actual Bulbine Natalensis extract. New innovations in scar management. © 2020 Springer Nature Switzerland AG. It looks effective with blue flowers in spring, or lime-coloured leaves. Curr Opin Drug Dis Dev. Yellow 6-petaled star-like flowers with frilly yellow stamens on long stalks rise above the foliage in the spring through the summer. Halder SK, Beauchamp RD, Datta PK. This is a clumping succulent and it continues with our theme of trying to promote plants that use less water but are still very beautiful in our landscape. Bulbine frutescens is an undemanding plant. Note that the native leek (Bulbine bulbosa) is regarded as a toxic plant, as it can poison cattle. Flavonoids are an important class of phytochemical. 2017;51:1089–103. It has been suggested that this is due to an activated form of HSP90 in tumor cells. However, problems such as toxicity and drug resistance have stimulated an intense demand and research e orts for the 2006;35:301–3. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. The incisional wounds were used to test tensile strength of the healed wounds using a tensiometer.In the in vitro studies, neither extract caused cytotoxicity to either the fibroblast or keratinocyte cells. Planting and Care. LigPlot+: multiple ligand–protein interaction diagrams for drug discovery. Some species of Bulbine have toxic foliage (e.g. 2009;12:189–96. This succulent perennial plant (ht 40 cm) grows in wide clumps with fleshy leaves and has dainty spires of yellow starry flowers mainly in spring but also at other times during the year. J Enzyme Inhib Med Chem. Bulbine plants are adaptable to many soil types. PLoS One. The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1. Bulbine is a very important plant from Tender Perennial. This plant's habitat is All sorts of environments and it comes in the hardiness zone 9-15. Animal studies show that it may increase testosterone, but only at specific doses - too high doses can have a negative impact on long-term health. Open babel: an open chemical toolbox. In my experience, it multiplies rapidly. Bulbine frutescens. Bulbine frutescens, which occurs in South Africa (in the provinces of Free State, 9 Northern Cape, Eastern Cape, Western Cape, and KwaZulu-Natal), Swaziland, 6 and Lesotho, 7 has yellow, sometimes orange, star-shaped flowers. Methylated flavonoids. 2003;66:1475–83. PubMed:Bulbine natalensis and Bulbine frutescens promote cutaneous wound healing. Hey AM, just happened to be researching and combing through the web looking up different test boosters and supplements containing some of these compounds touted at being big time natural test boosters and well reading several reviews/studies on one in particular by the name of bulbine … 3) Fungal Infections A class of naturally occurring chemicals (phytosterols) found in Bulbine natalensis blocked the growth of one of the most toxic fungi (Aspergillus flavus) [ 10 ]. Medicine (Baltimore). A large number of natural products have shown in vitro antiplasmodial activities. Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo. 2000;24:227–34. Int J Oncol. Bulbine likes full sun, but will grow well in semi-shade. Pinar R. To investigate knowledge of Turkish people about cancer. Tanespimycin is a potent HSP90 inhibitor with an IC 50 = 5 nM in a cell-free assay when HSP90 is isolated from tumor cells compared to c.500 nM when HSP90 is derived from normal cells. Laskowski RA, Swindells MB. In conclusion, Palmidin C, AC1NSTKE and Bulbine-knipholone are the novel potent anticancer phytochemicals and need to be studied further in vitro and in vivo. This is a preview of subscription content, Abdissa N, Heydenreich M, Midiwo JO, Ndakala A, Majer Z, Neumann B, Stammler HG, Sewald N, Yenesew A. O’Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR. The root, leaf, and stem are used as medicine. Cancer is a major public health burden in both developed and developing countries. The isofuranonaphthoquinone occurs in Bulbine plant species such as Bulbine abyssinica, Bulbine capitata, and B. frutescens. 2012;115:221–63. Afr J Tradit Complement Altern Med. Bulbine frutescens (Asphodelaceae), a traditional medicinal plant in South Africa possess bioactive flavonoids and terpenoids. Furthermore, drug-likeness property, ADME/T (absorption, distribution, metabolism, excretion/toxicity) properties, interaction ability with xenobiotic enzymes and biological activities were predicted by using various computational tools. Jelly juice bulbiny shrub (Bulbine frutescens) comprises anthraquinoneknifolon and mucopolysaccharides and glycoproteins (aloktin) that has medical properties of … 2011;51:2778–86. 2008;4:217–41. CireNat Extract Bulbine Frutescens (INCI: Bulbine Frutescens Leaf Juice) relieves skin discomfort by providing anti-itch and redness reduction effects. 217.16.190.11. The quinone moiety has been shown to possess antitumor activity and several cancer drugs in clinical use contain this entity. J Comput Chem. The juice of Bulbine annua, B. lagopus is said to have antibacterial and antifungal properties when applied externally. Bulbine is also an ingredient in the first-aid herbal wound cream made during the practical session. Carcinogenesis. 2011;26:460–7. van Huyssteen M, Milne PJ, Campbell EE, van de Venter M. Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. It combines beautifully with blue dwarf agapanthus, flowering at the same time. The linear leaves have a jelly-like juice that can apparently be used for burns, rashes, cracked skin and other dermatological ailments. Bulbine … 2005;28:249. Bulbine frutescens. According to the concept of various signaling involvement in the development of cancer, fractional inhibition of numerous targets can be more productive than single one. Cell proliferation was greater than 100% at 0.1-5 and 100-300 μg/ml for Bulbine natalensis and at 0.1μg/ml for Bulbine frutescens. 2011;3:33. 2007;28:1918–27. It is very easily propagated from division of the clump. Cancer stem cell signaling pathways. PubMed: Antidiabetic and cytotoxicity screening of five medicinal plants used by traditional African health practitioners in the Nelson Mandela Metropole, South Africa. Not affiliated The blue felicia bush goes well with bulbs like Agapanthus, Bulbine frutescens (stalked bulbine), Eucomis autumnalis (pineapple flower), Hypoxis hemerocallidea (star flower or African potato) and Watsonia. J Global Pharma Tech. The worldwide Protein Data Bank (wwpdb): ensuring a single, uniform archive of PDB data. Kaliberov SA, Buchsbaum DJ. Over 10 million scientific documents at your fingertips. J Chem Inf Model. J Comput Chem. In conclusion, our study shows that the isofuranonaphthoquinone isolated from Bulbine frutescens possesses antiproliferative effects on Jurkat T cells. Mouli KC, Vijaya T, Rao SD. 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